Prevention of cardiovascular events and primary hyperlipidemia in adult patients (including HeFH and ASCVD)
The recommended dose for Repatha® is either 140 mg every two weeks or 420 mg once monthly; both doses are clinically equivalent. When switching dosage regimens, administer the first dose of the new
regimen on the next scheduled date of the prior regimen.
- One prefilled autoinjector delivers the 140 mg every two-weeks dose
- One single-use automated mini-doser with 3.5 mL prefilled cartridge delivers the 420 mg once-monthly dose
- Alternatively, three prefilled autoinjectors administered consecutively within 30 minutes delivers the 420 mg once-monthly dose
Homozygous familial hypercholesterolemia
The initial recommended dose is 420 mg once monthly. After 12 weeks of treatment, dose frequency can be up-titrated to 420 mg once every two weeks if a clinically meaningful response is not achieved. Patients
on apheresis may initiate treatment with 420 mg every two weeks to correspond with their apheresis schedule.
- One automated mini-doser with prefilled cartridge delivers the 420 mg once monthly dose
- Alternatively, three prefilled autoinjectors administered consecutively within 30 minutes deliver the 420 mg once monthly or 420 mg every two-weeks dose
Please see the Product Monograph for complete dosing and drug interaction information.
